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It has, for example, been observed that mood is improved within the first two weeks of a diet irrespective of macronutrient composition (Rosen et al., 1985), and only one study, to our knowledge, has demonstrated a correlation between ketone levels and memory performance (Krikorian et al., 2012). It’s unclear at this time whether an elevation in ketones over and above NK would mitigate the effects of keto-induction. While it is clear that exogenous ketones increase serum BOHB, they are not ketogenic, and may, in fact, inhibit endogenous ketone production (Balasse & Neef, 1975). In a study using higher dosages (0.573 g/kg BW) in healthy male athletes performing an hour of bicycle exercise at 75% of maximal exercise intensity BOHB levels rose from 0.1 to 3.4 mmol/L (p Cox et al., 2015). Ketone esters (KEs) at the time of writing, are only available for research, primarily as 1,3-butanediol monoester of BOHB (Hashim & Van Itallie, 2014) and thus, the animal and human research has mostly focused on the use of ketone esters. Ketone supplements might also improve fueling during exercise, reduce lactate production, and improve performance due to glucose sparing (Okuda et al., 1991), and have positive effects on anxiety (Kashiwaya et al., 2013), and mental performance and memory (Kashiwaya et al., 2013). They are considered to be a safe and effective way to increase ketone body concentrations (Hashim & Van Itallie, 2014). However, ketogenesis is reduced by the simultaneous application of glucose (Kolb & Sailer, 1984). When fed intravenously, MCTs increase ketogenesis when compared to both structurally similar fats (Mingrone et al., 1993) and LCTs (Jiang et al., 1993; Lai & Chen, 2000). Dietary MCTs are also known to promote both ketonaemia and ketogenesis in animals (Bach et al., 1977; Yeh & Zee, 1976) and humans with and without health conditions (St-Onge et al., 2003; Yajnik et al., 1997). Similar to the short-chain fatty acids and unlike long-chain triglycerides (LCTs), MCTs do not require the actions of bile, nor micellar-chylomicron mediated absorption into the lymphatics and instead are diffused directly into the hepatic portal vein and preferentially converted into bio-available ketone bodies in the liver. Both 2 g and 4 g of butyric acid were demonstrated to be more ketogenic than either 5 g of leucine, or 5 or 10 g of O-MAG (St-Pierre et al., 2017). For example, silage butyrate content has been shown to provide no significant effect on subclinical ketosis in dairy cows (Samiei et al., 2015), however, sub-clinical ketosis is higher in those receiving silage higher in butyrate content (Vicente et al., 2014). 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